Issue 11, 2011

Gas-phase binding energies for non-covalent Aβ-40 peptide/small molecule complexes from CIDmass spectrometry and RRKM theory

Abstract

The gas-phase binding of small molecules to the Amyloid β-40 peptide generated by electrospray ionization has been explored with collision-induced dissociation mass spectrometry and kinetic rate theory. This study discusses a simple procedure used to theoretically model the experimental breakdown diagrams for the Aβ-40 peptide complexed with a series of aminosulfonate small molecules, namely homotaurine, 3-cyclohexylamino-2-hydroxy-1-propanesulfonic acid (CAPSO), 3-(1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)propane-1-sulfonic acid, 3-(1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)butane-1-sulfonic acid, and 3-(cyclohexylamino)propane-1-sulfonic acid. An alternative procedure employing an extrapolation procedure for k(E) is also discussed.

Graphical abstract: Gas-phase binding energies for non-covalent Aβ-40 peptide/small molecule complexes from CID mass spectrometry and RRKM theory

Article information

Article type
Paper
Submitted
13 Oct 2010
Accepted
13 Jan 2011
First published
07 Feb 2011

Phys. Chem. Chem. Phys., 2011,13, 5178-5186

Gas-phase binding energies for non-covalent Aβ-40 peptide/small molecule complexes from CID mass spectrometry and RRKM theory

P. M. Mayer and E. Martineau, Phys. Chem. Chem. Phys., 2011, 13, 5178 DOI: 10.1039/C0CP02149K

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