Issue 37, 2011
From the journal:

Chemical Communications

cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands†‡

Cristina Airoldi,a   Francisco Cardona,ab   Erika Sironi,a   Laura Colombo,c   Mario Salmona,c   Artur Silva,b   Francesco Nicotraa  and  Barbara La Ferla*a  

* Corresponding authors

a Dept. of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126, Milan, Italy
E-mail: barbara.laferla@unimib.it
Fax: +39 0264483565
Tel: +39 0264483421

b Dept. of Chemistry, University of Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro, Portugal

c Dept. of Molecular Biochemistry and Pharmacology Mario Negri Institute for Pharmacological Research, via La Masa 19, 20156, Milan, Italy

Abstract

A small library of glyco-fused benzopyran compounds has been synthesised. Their interaction features with Aβ peptides have been characterised by using STD-NMR and trNOESY experiments. The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations.

Graphical abstract: cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

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Article information

DOI
https://doi.org/10.1039/C1CC13046C
Article type
Communication
Submitted
24 May 2011
Accepted
28 Jul 2011
First published
22 Aug 2011

Chem. Commun., 2011,47, 10266-10268

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cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands

C. Airoldi, F. Cardona, E. Sironi, L. Colombo, M. Salmona, A. Silva, F. Nicotra and B. La Ferla, Chem. Commun., 2011, 47, 10266 DOI: 10.1039/C1CC13046C

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