Issue 15, 2011

One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

Abstract

An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and 4-nitrobut-1-yne under a combination of base and gold(III) catalysis is reported.

Graphical abstract: One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

Supplementary files

Article information

Article type
Communication
Submitted
08 Feb 2011
Accepted
15 Feb 2011
First published
28 Mar 2011

Chem. Commun., 2011,47, 4379-4381

One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis

D. M. Barber, H. Sanganee and D. J. Dixon, Chem. Commun., 2011, 47, 4379 DOI: 10.1039/C1CC10751H

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