Issue 11, 2011
From the journal:

Chemical Communications

A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging†

Flora L. Thorp-Greenwood,‡a   Vanesa Fernández-Moreira,‡a   Coralie O. Millet,b   Catrin F. Williams,b   Joanne Cable,b   Jonathan B. Court,b   Anthony J. Hayes,c   David Lloydb  and  Michael P. Coogan*a  

* Corresponding authors

a Department of Chemistry, Cardiff University, Cardiff, Cymru/Wales, UK
E-mail: cooganmp@cf.ac.uk
Fax: +44 (0)2920874030
Tel: +44 (0)2920874066

b Cardiff School of Biosciences, Main Building, Museum Avenue, Cardiff, Cymru/Wales, UK

c Confocal Microscopy Unit, Cardiff School of Biosciences, Life Sciences Building, Cardiff, Wales, UK

Abstract

A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.

Graphical abstract: A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

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Article information

DOI
https://doi.org/10.1039/C1CC10141B
Article type
Communication
Submitted
07 Jan 2011
Accepted
27 Jan 2011
First published
11 Feb 2011

Chem. Commun., 2011,47, 3096-3098

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A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

F. L. Thorp-Greenwood, V. Fernández-Moreira, C. O. Millet, C. F. Williams, J. Cable, J. B. Court, A. J. Hayes, D. Lloyd and M. P. Coogan, Chem. Commun., 2011, 47, 3096 DOI: 10.1039/C1CC10141B

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