Issue 7, 2011
From the journal:

Polymer Chemistry

Polymersomes enhance the immunogenicity of influenza subunit vaccine†

Christophe Barnier Quer,‡a   Hana Robson Marsden,‡b   Stefan Romeijn,a   Harshal Zope,b   Alexander Kros*b  and  Wim Jiskoot*a  

* Corresponding authors

a Division of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, P.O. Box 9502, Leiden, The Netherlands
E-mail: w.jiskoot@lacdr.leidenuniv.nl
Tel: +31 71 527 4314

b Department of Soft Matter Chemistry, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, Leiden, The Netherlands

Abstract

In this study poly(γ-benzyl-L-glutamate)-K (PBLG50-K) polymersomes are tested as an immune adjuvant for an antigen, influenza hemagglutinin (HA). The polymersomes were prepared according to a solvent removal method and loaded with HA antigensvia adsorption. The immunogenicity of the resulting hybrid assemblies was tested in vivo, resulting in an improvement of the immune response for the influenza antigen co-administered with the polymersomes.

Graphical abstract: Polymersomes enhance the immunogenicity of influenza subunit vaccine

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Article information

DOI
https://doi.org/10.1039/C1PY00010A
Article type
Communication
Submitted
11 Jan 2011
Accepted
03 Mar 2011
First published
29 Mar 2011

Polym. Chem., 2011,2, 1482-1485

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Polymersomes enhance the immunogenicity of influenza subunit vaccine

C. Barnier Quer, H. Robson Marsden, S. Romeijn, H. Zope, A. Kros and W. Jiskoot, Polym. Chem., 2011, 2, 1482 DOI: 10.1039/C1PY00010A

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