Issue 11, 2011
From the journal:

Organic & Biomolecular Chemistry

Synthesis of novel chromene scaffolds for adenosine receptors†

Marta Costa,a   Filipe Areias,ab   Marian Castro,b   Jose Brea,b   María I. Lozab  and  Fernanda Proença*a  

* Corresponding authors

a Department of Chemistry, University of Minho, Campos de Gualtar, Braga, Portugal
E-mail: fproenca@quimica.uminho.pt
Fax: +0-351-253-604383
Tel: +0-351-253604379

b Department of Pharmacology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain

Abstract

A one-pot procedure was developed for the synthesis of novel 3-[amino(methoxy)methylene]-2-oxo-3,4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno[3,4-c]pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.

Graphical abstract: Synthesis of novel chromene scaffolds for adenosine receptors

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Article information

DOI
https://doi.org/10.1039/C1OB05305A
Article type
Paper
Submitted
24 Feb 2011
Accepted
25 Mar 2011
First published
20 Apr 2011

Org. Biomol. Chem., 2011,9, 4242-4249

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Synthesis of novel chromene scaffolds for adenosine receptors

M. Costa, F. Areias, M. Castro, J. Brea, M. I. Loza and F. Proença, Org. Biomol. Chem., 2011, 9, 4242 DOI: 10.1039/C1OB05305A

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