Issue 11, 2011
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water†

Hidemasa Hikawa*a  and  Yuusaku Yokoyama*a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
E-mail: hidemasa.hikawa@phar.toho-u.ac.jp
Fax: +81-47-472-1595
Tel: +81-47-472-1591

Abstract

Palladium-catalyzed N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol were carried out. The reaction in the presence of Pd(OAc)2 (5 mol%), sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol%), and AcONa (2 equiv) in water at 120 °C for 16 h in a sealed tube gave only mono-N-allylated amino acids in good yield.

Graphical abstract: Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1OB05238A
Article type
Paper
Submitted
15 Feb 2011
Accepted
23 Mar 2011
First published
24 Mar 2011

Org. Biomol. Chem., 2011,9, 4044-4050

Permissions

Request permissions

Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water

H. Hikawa and Y. Yokoyama, Org. Biomol. Chem., 2011, 9, 4044 DOI: 10.1039/C1OB05238A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements