Issue 8, 2011
From the journal:

Natural Product Reports

Piperazic acid-containing natural products: Isolation, biological relevance and total synthesis

Alexander J. Oelke,ab   David J. France,c   Tatjana Hofmann,d   Georg Wuitschike  and  Steven V. Ley*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK

b Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Room 18–344, Cambridge, MA, USA

c WestCHEM School of Chemistry, University of Glasgow, University Ave., Glasgow, UK

d Merck Serono Medicinal Chemistry Darmstadt, Merck KGaA, Frankfurter Straße 250, Darmstadt, Germany

e F. Hoffmann-La Roche Ltd, pRED, Therapeutic Modalities, Synthesis & Process Research, Basel, Switzerland

Abstract

Covering: up to 2010

Since their first discovery in 1959, natural products containing the piperazic acid motif have been isolated from a variety of sources and exhibit diverse biological activity profiles. This review provides information about their isolation and biological activities, and presents an overview of recent total syntheses of these molecules.

Graphical abstract: Piperazic acid-containing natural products: Isolation, biological relevance and total synthesis

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Article information

DOI
https://doi.org/10.1039/C1NP00041A
Article type
Review Article
Submitted
04 May 2011
First published
05 Jul 2011

Nat. Prod. Rep., 2011,28, 1445-1471

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Piperazic acid-containing natural products: Isolation, biological relevance and total synthesis

A. J. Oelke, D. J. France, T. Hofmann, G. Wuitschik and S. V. Ley, Nat. Prod. Rep., 2011, 28, 1445 DOI: 10.1039/C1NP00041A

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