Issue 47, 2011
From the journal:

Journal of Materials Chemistry

Strong supramolecular control over proteinself-assembly using a polyamine decorated β-cyclodextrin as synthetic recognition element†‡

Dana A. Uhlenheuer,§a   Lech-Gustav Milroy,§a   Pauline Neiryncka  and  Luc Brunsveld*a  

* Corresponding authors

a Laboratory of Chemical Biology, Department of Biomedical Engineering, Technische Universiteit Eindhoven, Den Dolech 2, Eindhoven, The Netherlands
E-mail: l.brunsveld@tue.nl
Fax: (+31) 40 247 8367
Tel: (+31) 40 247 3737

Abstract

The supramolecular host molecule heptakis-[6-deoxy-6-(2-aminoethylsulfanyl)]-β-cyclodextrin provides strong control over protein self-assembly in synthetic supramolecular protein constructs. Mono-functionalization of this modified β-cyclodextrin with a cysteine residue allows for site-selective synthetic conjugation to a protein and formation of a highly stable synthetic protein complex with a lithocholic acid conjugated protein as the interaction partner.

Graphical abstract: Strong supramolecular control over protein self-assembly using a polyamine decorated β-cyclodextrin as synthetic recognition element

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Article information

DOI
https://doi.org/10.1039/C1JM12736E
Article type
Communication
Submitted
14 Jun 2011
Accepted
04 Aug 2011
First published
23 Aug 2011

J. Mater. Chem., 2011,21, 18919-18922

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Strong supramolecular control over protein self-assembly using a polyamine decorated β-cyclodextrin as synthetic recognition element

D. A. Uhlenheuer, L. Milroy, P. Neirynck and L. Brunsveld, J. Mater. Chem., 2011, 21, 18919 DOI: 10.1039/C1JM12736E

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