Issue 47, 2011
From the journal:

Chemical Communications

Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe†

Tae-Il Kim,a   Jihye Park,a   Seonhwa Park,b   Yongdoo Choi*b  and  Youngmi Kim*a  

* Corresponding authors

a Department of Chemistry, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do, Korea
E-mail: youngmi@dankook.ac.kr
Fax: +82 31-8005-3148
Tel: +82 31-8005-3156

b Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Korea
E-mail: ydchoi@ncc.re.kr
Fax: +82 31-920-2529
Tel: +82 31-920-2512

Abstract

We have presented a fluorescent probe 1 that exhibits a fluorescence turn-on signal upon reaction with tyrosinase, and we show that it is readily employed for the assessment of tyrosinase activity and tyrosinase inhibitor activity in buffered aqueous solution, and further utilized for the visualization of endogenous tyrosinase activity in living melanoma cells.

Graphical abstract: Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe

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Article information

DOI
https://doi.org/10.1039/C1CC15061H
Article type
Communication
Submitted
15 Aug 2011
Accepted
30 Sep 2011
First published
26 Oct 2011

Chem. Commun., 2011,47, 12640-12642

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Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe

T. Kim, J. Park, S. Park, Y. Choi and Y. Kim, Chem. Commun., 2011, 47, 12640 DOI: 10.1039/C1CC15061H

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