Issue 2, 2010

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Abstract

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

Graphical abstract: Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Supplementary files

Article information

Article type
Edge Article
Submitted
25 Jan 2010
Accepted
12 Feb 2010
First published
25 May 2010

Chem. Sci., 2010,1, 206-209

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

D. Morisaki, H. Kim, H. Inoue, H. Terauchi, S. Kuge, A. Naganuma, Y. Wataya, H. Tokuyama, M. Ihara and K. Takasu, Chem. Sci., 2010, 1, 206 DOI: 10.1039/C0SC00125B

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