Issue 36, 2010
From the journal:

Chemical Communications

A general glycomimetic strategy yields non-carbohydrateinhibitors of DC-SIGN†

Kathleen C. A. Garber,a   Kittikhun Wangkanont,a   Erin E. Carlsona  and  Laura L. Kiessling*ab  

* Corresponding authors

a Department of Chemistry, University of Wisconsin—Madison, 1101 University Avenue, Madison, USA
E-mail: kiessling@chem.wisc.edu
Fax: +1 608 265 0764

b Department of Biochemistry, University of Wisconsin—Madison, 433 Babcock Drive, Madison, USA

Abstract

Shikimic acid can be transformed into monovalent and multivalent glycomimetics that target different members of the C-type lectin class, including DC-SIGN, a dendritic cell lectin that facilitates HIV transmission.

Graphical abstract: A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN

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Article information

DOI
https://doi.org/10.1039/C0CC00830C
Article type
Communication
Submitted
08 Apr 2010
Accepted
21 Jun 2010
First published
18 Aug 2010

Chem. Commun., 2010,46, 6747-6749

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A general glycomimetic strategy yields non-carbohydrate inhibitors of DC-SIGN

K. C. A. Garber, K. Wangkanont, E. E. Carlson and L. L. Kiessling, Chem. Commun., 2010, 46, 6747 DOI: 10.1039/C0CC00830C

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