Issue 3, 2010
From the journal:

Photochemical & Photobiological Sciences

A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers

Angeles Villanueva,*a   Juan Carlos Stockert,ab   Magdalena Cañetea  and  Pilar Acedoa  

* Corresponding authors

a Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Darwin 2, Edificio de Biología, Madrid, Spain
E-mail: angeles.villanueva@uam.es
Fax: +34 91 4978344

b Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, Madrid, Spain

Abstract

The combined application of two photosensitisers (PSs), zinc(II) phthalocyanine (ZnPc) and the cationic porphyrin meso-tetrakis(4-N-methylpyridyl)porphine (T4MPyP), on HeLa cells produced an enhanced lethal effect relative to treatments with single PSs. Thus, the proper combination of PSs may constitute a new strategy to improve the efficacy of clinical photodynamic therapy.

Graphical abstract: A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers

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Article information

DOI
https://doi.org/10.1039/B9PP00153K
Article type
Communication
Submitted
02 Nov 2009
Accepted
28 Dec 2009
First published
27 Jan 2010

Photochem. Photobiol. Sci., 2010,9, 295-297

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A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers

A. Villanueva, J. C. Stockert, M. Cañete and P. Acedo, Photochem. Photobiol. Sci., 2010, 9, 295 DOI: 10.1039/B9PP00153K

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