Issue 24, 2010
From the journal:

Organic & Biomolecular Chemistry

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition†

P. Matthew Joyner,a   Jinman Liu,b   Zhijun Zhang,b   Justin Merritt,b   Fengxia Qib  and  Robert H. Cichewicz*ac  

* Corresponding authors

a Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK, U.S.A
E-mail: rhcichewicz@ou.edu
Tel: +1 (405) 325-6969

b College of Dentistry, 975 NE 10th Street, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

c Graduate Program in Ecology and Evolutionary Biology, University of Oklahoma, Norman, OK, USA, USA

Abstract

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

Graphical abstract: Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

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Article information

DOI
https://doi.org/10.1039/C0OB00579G
Article type
Communication
Submitted
13 Aug 2010
Accepted
06 Sep 2010
First published
20 Sep 2010

Org. Biomol. Chem., 2010,8, 5486-5489

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Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition

P. M. Joyner, J. Liu, Z. Zhang, J. Merritt, F. Qi and R. H. Cichewicz, Org. Biomol. Chem., 2010, 8, 5486 DOI: 10.1039/C0OB00579G

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