Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex†
Abstract
Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A–C (1–3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1–3 significantly inhibited the accumulation of the pro-inflammatory iNOS