Issue 7, 2010
From the journal:

CrystEngComm

Crystallization of cyclosporin A in lyotropic reverse hexagonal liquid crystals

Dima Libster,a   Abraham Aserin,a   Idit Amar-Yuli,a   Tehila Mishraki,a   Yael Domovich-Eisenberg,b   Oded Livnahb  and  Nissim Garti*a  

* Corresponding authors

a Casali Institute of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel
E-mail: garti@vms.huji.ac.il
Fax: +972-2-652-0262
Tel: +972-2-658-6574/5

b Department of Biological Chemistry, The Institute of Life Sciences, The Wolfson Centre for Applied Structural Biology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel

Abstract

In this communication we demonstrate for the first time that lyotropic reverse hexagonal mesophase can serve as a crystallization medium for a hydrophobic peptide, resulting in high quality single crystals suitable for crystallographic analysis. The obtained crystals of cyclosporin A enabled excellent X-ray data collection, diffracting to a resolution limit of 1.0 Å. Current findings open a new perspective in the field of crystallization of biological macromolecules in lyotropic mesophases.

Graphical abstract: Crystallization of cyclosporin A in lyotropic reverse hexagonal liquid crystals

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Article information

DOI
https://doi.org/10.1039/C001263G
Article type
Communication
Submitted
19 Jan 2010
Accepted
29 Mar 2010
First published
13 Apr 2010

CrystEngComm, 2010,12, 2034-2036

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Crystallization of cyclosporin A in lyotropic reverse hexagonal liquid crystals

D. Libster, A. Aserin, I. Amar-Yuli, T. Mishraki, Y. Domovich-Eisenberg, O. Livnah and N. Garti, CrystEngComm, 2010, 12, 2034 DOI: 10.1039/C001263G

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