Issue 34, 2010
From the journal:

Chemical Communications

Salt concentration-induced dehybridisation of DNA–gold nanoparticle conjugate assemblies for diagnostic applications†

Ju-Hwan Oha  and  Jae-Seung Lee*a  

* Corresponding authors

a Department of Materials Science and Engineering and Institute for Biomedical Research, Korea University, Anam-dong, Seongbuk-gu, Seoul, Republic of Korea
E-mail: jslee79@korea.ac.kr
Fax: +82 2-928-3584
Tel: +82 2-3290-3267

Abstract

We present the cooperative dehybridisation of DNA–gold nanoparticle conjugate (DNA–AuNP) assemblies induced by reduced salt concentration ([salt]), which can be precisely controlled by various conditions. The detection of Ag+ based upon the [salt]-induced dehybridisation of DNA–AuNP assemblies is five times more sensitive than that achieved under conventional thermal melting conditions.

Graphical abstract: Salt concentration-induced dehybridisation of DNA–gold nanoparticle conjugate assemblies for diagnostic applications

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Article information

DOI
https://doi.org/10.1039/C0CC01488E
Article type
Communication
Submitted
19 May 2010
Accepted
15 Jul 2010
First published
05 Aug 2010

Chem. Commun., 2010,46, 6382-6384

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Salt concentration-induced dehybridisation of DNA–gold nanoparticle conjugate assemblies for diagnostic applications

J. Oh and J. Lee, Chem. Commun., 2010, 46, 6382 DOI: 10.1039/C0CC01488E

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