Catalytic coupling of N-benzylic sulfonamides with silylated nucleophiles at room temperature

Abstract

In the presence of 2–10 mol% of Tf₂NH, a range of N-benzylic sulfonamides smoothly react with allylic, propargylic, benzylic, or hydrido silanes at room temperature via sp³ carbon–nitrogen bond cleavage to afford structurally diverse products in moderate to excellent yields and with high chemo- and regioselectivity.