Issue 33, 2010
From the journal:

Chemical Communications

Size-selective proteolysis on mesoporous silica-based trypsin nanoreactor for low-MW proteome analysis†

Qianhao Min,‡ab   Ren'an Wu,‡a   Liang Zhao,a   Hongqiang Qin,a   Mingliang Ye,a   Jun-Jie Zhu*b  and  Hanfa Zou*a  

* Corresponding authors

a CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, P. R. China
E-mail: hanfazou@dicp.ac.cn
Fax: (+86)-411-84379620

b Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: jjzhu@nju.edu.cn
Fax: (+86)-25-83594976

Abstract

In this study, the concept of size-selective proteolysis was first described by using the mesoporous silica-based trypsin nanoreactor. For analysis of a complex protein sample, low-MW proteins were preferentially digested for identification while high-MW proteins were excluded from digestion.

Graphical abstract: Size-selective proteolysis on mesoporous silica-based trypsin nanoreactor for low-MW proteome analysis

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Article information

DOI
https://doi.org/10.1039/C0CC00619J
Article type
Communication
Submitted
27 Mar 2010
Accepted
28 Jun 2010
First published
27 Jul 2010

Chem. Commun., 2010,46, 6144-6146

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Size-selective proteolysis on mesoporous silica-based trypsin nanoreactor for low-MW proteome analysis

Q. Min, R. Wu, L. Zhao, H. Qin, M. Ye, J. Zhu and H. Zou, Chem. Commun., 2010, 46, 6144 DOI: 10.1039/C0CC00619J

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