Total synthesis of (±)-aspercyclide A and its C19 methyl ether

James L. Carr; Daniel A. Offermann; Mary D. Holdom; Philip Dusart; Andrew J. P. White; Andrew J. Beavil; Robin J. Leatherbarrow; Stephen D. Lindell; Brian J. Sutton; Alan C. Spivey

doi:10.1039/B923528K

Total synthesis of (±)-aspercyclide A and its C19 methyl ether†

James L. Carr,^a Daniel A. Offermann,^a Mary D. Holdom,^b Philip Dusart,^b Andrew J. P. White,^a Andrew J. Beavil,^b Robin J. Leatherbarrow,^a Stephen D. Lindell,^c Brian J. Sutton^b and Alan C. Spivey*^a

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^a Department of Chemistry, South Kensington campus, Imperial College, London, UK
E-mail: a.c.spivey@imperial.ac.uk
Tel: +44 (0)20 75945841

^b King's College London, The Randall Division of Cell & Molecular Biophysics, New Hunt's House, Guy's Hospital Campus, London, UK

^c BayerCropScience AG, Industriepark Höchst G836, Frankfurt-am-Mein, Germany

Abstract

The total syntheses of (±)-aspercyclide A (1) and its C19 methyl ether (15a) featuring Heck–Mizoroki macrocyclisation to form the 11-membered (E)-styrenyl biaryl ether lactone core are described.

Chemical Communications

Total synthesis of (±)-aspercyclide A and its C19 methyl ether†

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Total synthesis of (±)-aspercyclide A and its C19 methyl ether

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