Issue 8, 2010

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

Abstract

We now present the first example in which triplet repeat DNAs adopt the i-motif structure at neutral pH by molecular crowding. Crowding stabilized the i-motif and the pKa of N3 of cytosine was raised in such a microenvironment. Molecular crowding is known to accelerate the formation of the multi-stranded i-motif while the triplet repeats adopt the single-strand structure.

Graphical abstract: Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

Supplementary files

Article information

Article type
Communication
Submitted
21 Oct 2009
Accepted
15 Dec 2009
First published
14 Jan 2010

Chem. Commun., 2010,46, 1299-1301

Molecular crowding of the cosolutes induces an intramolecular i-motif structure of triplet repeat DNA oligomers at neutral pH

A. Rajendran, S. Nakano and N. Sugimoto, Chem. Commun., 2010, 46, 1299 DOI: 10.1039/B922050J

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