Issue 34, 2009
From the journal:

Journal of Materials Chemistry

Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface

C. Piccirillo,a   S. Perni,c   J. Gil-Thomas,b   P. Prokopovich,d   M. Wilson,c   J. Prattenc  and  I. P. Parkin*a  

* Corresponding authors

a Materials Chemistry Research Centre, Department of Chemistry, University College London, 20 Gordon Street, London, United Kingdom
E-mail: i.p.parkin@ucl.ac.uk

b Departemento de Quimica Organica, Facultat de Farmacia, Universitat de Valencia, Avida Vincente Andres Estelles, Burjassot, Valencia, Spain

c Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Gray's Inn Road, London, United Kingdom

d Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, United Kingdom

Abstract

Methylene Blue or Toluidine Blue O were covalently bound to an activated silicone polymer by means of an amide condensation reaction. UV-visible absorption spectra confirmed that the dye was surface bound. The new polymers with covalently attached dye display significant bactericidal activity against Escherichia coli and Staphylococcus epidermidis with a 99.999% reduction in viable bacteria after four minutes exposure to a low power laser.

Graphical abstract: Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface

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Article information

DOI
https://doi.org/10.1039/B905495B
Article type
Paper
Submitted
18 Mar 2009
Accepted
05 Jun 2009
First published
06 Jul 2009

J. Mater. Chem., 2009,19, 6167-6171

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Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface

C. Piccirillo, S. Perni, J. Gil-Thomas, P. Prokopovich, M. Wilson, J. Pratten and I. P. Parkin, J. Mater. Chem., 2009, 19, 6167 DOI: 10.1039/B905495B

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