Issue 16, 2009
From the journal:

Journal of Materials Chemistry

Hybrid gadolinium oxide nanoparticles combining imaging and therapy

Jean-Luc Bridot,a   David Dayde,b   Charlotte Rivière,c   Céline Mandon,d   Claire Billotey,d   Stéphanie Lerondel,e   Roland Sabattier,f   Guillaume Cartron,g   Alain Le Pape,e   Gilbert Blondiaux,h   Marc Janier,d   Pascal Perriat,i   Stéphane Roux*a  and  Olivier Tillementa  

* Corresponding authors

a Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS – Université Claude Bernard Lyon 1, Villeurbanne Cedex, France
E-mail: roux@pcml.univ-lyon1.fr
Fax: +33 472 43 12 33
Tel: +33 472 43 12 00

b Laboratoire d'immunologie, EA 3853 IPGA Faculté de Médecine, Tours Cedex, France

c Laboratoire de Physique de la Matière Condensée et Nanostructures, UMR 5586 CNRS–Université Claude Bernard Lyon 1, Villeurbanne Cedex, France

d Laboratoire CREATIS–Animage, UMR 5515 CNRS – U630 INSERM – INSA de Lyon – Université Claude Bernard Lyon 1, Villeurbanne Cedex, France

e Centre de Distribution, Typage et Archivage Animal, UPS CNRS 44, 3B rue de la Férollerie, Orléans, France

f Service de radiologie, Centre Hospitalier Régional d'Orléans, Orléans, France

g Service d'hématologie et de biothérapie, U847 INSERM, Centre Hospitalier Universitaire Lapeyronnie, Montpellier, France

h CERI-CNRS Centre d'Etudes et de Recherches par Irradiation, 3A rue de la Férollerie, Orléans cedex 2, France

i MATEIS, UMR 5510 CNRS – INSA de Lyon, Villeurbanne Cedex, France

Abstract

The cytotoxicity of luminescent paramagnetic gadolinium oxide nanoparticles activated by harmless thermal neutron irradiation was evaluated on a luciferase coding gene transfected lymphome cells (EL4-Luc). Cellular uptake of nanoparticles was determined by fluorescence and magnetic resonance imaging and by ICP-MS analyses while the metabolic activity of irradiated EL4-Luc cells was monitored by bioluminescence. The alteration of the irradiated cells depends both on neutron irradiation dose and on gadolinium content within cells. In addition to their dual modality imaging ability, the application of these multifunctional particles for neutron capture therapy can be envisaged.

Graphical abstract: Hybrid gadolinium oxide nanoparticles combining imaging and therapy

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Article information

DOI
https://doi.org/10.1039/B815836C
Article type
Paper
Submitted
10 Sep 2008
Accepted
14 Jan 2009
First published
02 Mar 2009

J. Mater. Chem., 2009,19, 2328-2335

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Hybrid gadolinium oxide nanoparticles combining imaging and therapy

J. Bridot, D. Dayde, C. Rivière, C. Mandon, C. Billotey, S. Lerondel, R. Sabattier, G. Cartron, A. Le Pape, G. Blondiaux, M. Janier, P. Perriat, S. Roux and O. Tillement, J. Mater. Chem., 2009, 19, 2328 DOI: 10.1039/B815836C

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