Issue 2, 2009

Novel ((3Z,5Z)-3,5-bis(phenylimino)-1,2-dithiolan-4-yl) and 3H-[1,2]dithiolo[3,4-b]quinolin-4(9H)-one heterocycles: an effective and facile green route

Abstract

Two new sulfur heterocycle systems containing a 1,2-dithiole group, have been synthesized and characterized by IR, 1H NMR and single crystal X-ray crystallography. Optimum conditions for these closed-ring reactions have been studied and the possible reaction mechanism has been explored. A simple, fast, inexpensive and clean green synthesis route has been described here. The anti-cancer activity of these compounds was evaluated in terms of cell growth inhibition against human liver cancer cells HepG2.

Graphical abstract: Novel ((3Z,5Z)-3,5-bis(phenylimino)-1,2-dithiolan-4-yl) and 3H-[1,2]dithiolo[3,4-b]quinolin-4(9H)-one heterocycles: an effective and facile green route

Supplementary files

Article information

Article type
Paper
Submitted
29 May 2008
Accepted
31 Oct 2008
First published
19 Nov 2008

Green Chem., 2009,11, 215-222

Novel ((3Z,5Z)-3,5-bis(phenylimino)-1,2-dithiolan-4-yl) and 3H-[1,2]dithiolo[3,4-b]quinolin-4(9H)-one heterocycles: an effective and facile green route

F. Jian, J. Zheng, Y. Li and J. Wang, Green Chem., 2009, 11, 215 DOI: 10.1039/B808949C

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