Issue 47, 2009
From the journal:

Chemical Communications

Label-free dual assay of DNA sequences and potassium ions using an aptamer probe and a molecular light switch complex†

Min Sun Choi,a   Minji Yoon,a   Jin-Ook Baegb  and  Jinheung Kim*a  

* Corresponding authors

a Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea
E-mail: jinheung@ewha.ac.kr
Fax: (+82) 2-3277-3419

b Advanced Chemical Technology Division, Korea Research Institute of Chemical Technology (KRICT), 100 Jang-dong, Yuseong-gu, Korea

Abstract

A homogeneous assay is reported using Ru(phen)2(dppz)2+ and a K+-binding aptamer for the selective and sensitive detection of a target oligonucleotide and potassium ions, based on reduction in fluorescence emission according to the formation of the G-quadruplex structure from the aptamer in the presence of K+.

Graphical abstract: Label-free dual assay of DNA sequences and potassium ions using an aptamer probe and a molecular light switch complex

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Article information

DOI
https://doi.org/10.1039/B915994K
Article type
Communication
Submitted
04 Aug 2009
Accepted
06 Oct 2009
First published
22 Oct 2009

Chem. Commun., 2009, 7419-7421

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Label-free dual assay of DNA sequences and potassium ions using an aptamer probe and a molecular light switch complex

M. Sun Choi, M. Yoon, J. Baeg and J. Kim, Chem. Commun., 2009, 7419 DOI: 10.1039/B915994K

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