Issue 18, 2009
From the journal:

Chemical Communications

Quantum dots-gold(iii)-based indirect fluorescence immunoassay for high-throughput screening of APP†

Zonghai Sheng,a   Heyou Han,*a   Dehong Hu,ac   Jiangong Liang,a   Qigai He,b   Meilin Jin,b   Rui Zhoub  and  Huanchun Chenb  

* Corresponding authors

a College of Science, State Key Laboratory of Agricultural Microbiology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, PR China
E-mail: hyhan@mail.hzau.edu.cn
Fax: +86-027-87288246
Tel: +86-027-87288246

b College of Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, PR China

c Key Laboratory for Biomedical informatics and Health Engineering, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, Shenzhen, PR China

Abstract

Here we report a indirect fluorescence immunoassay for high-throughput screening of APP based on the fluorescence quenching of quantum dots by gold(III), which were dissolved from gold nanoparticles-Rabbit anti-Pig IgG conjugate, and further utilize this system to detect APP in pig serum with high sensitivity and specificity.

Graphical abstract: Quantum dots-gold(iii)-based indirect fluorescence immunoassay for high-throughput screening of APP

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Article information

DOI
https://doi.org/10.1039/B822921J
Article type
Communication
Submitted
19 Dec 2008
Accepted
18 Feb 2009
First published
18 Mar 2009

Chem. Commun., 2009, 2559-2561

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Quantum dots-gold(III)-based indirect fluorescence immunoassay for high-throughput screening of APP

Z. Sheng, H. Han, D. Hu, J. Liang, Q. He, M. Jin, R. Zhou and H. Chen, Chem. Commun., 2009, 2559 DOI: 10.1039/B822921J

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