Issue 9, 2009

Significant steroids: effective and general synthesis of 4α- and 4β-amino-5α-androstanes

Abstract

4α-Aminosteroids were synthesized by the substitution of a 2α-bromo ketone using K2CO3 as an activator; 4β-aminosteroids were synthesized in excellent yields by a highly regioselective and trans-stereospecific ring opening of a steroidal 3,4α-epoxide using ZnCl2H2O as a catalyst.

Graphical abstract: Significant steroids: effective and general synthesis of 4α- and 4β-amino-5α-androstanes

Supplementary files

Article information

Article type
Communication
Submitted
13 Oct 2008
Accepted
29 Dec 2008
First published
27 Jan 2009

Chem. Commun., 2009, 1037-1039

Significant steroids: effective and general synthesis of 4α- and 4β-amino-5α-androstanes

X. Ke, H. Hu, K. Zhang, W. Xu, Q. Zhu, L. Wu and X. Hu, Chem. Commun., 2009, 1037 DOI: 10.1039/B817910G

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