Issue 8, 2009
From the journal:

Analyst

Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis

Andrew D. Burnett,*a   Wenhui Fan,†a   Prashanth C. Upadhya,‡a   John E. Cunningham,a   Michael D. Hargreaves,b   Tasnim Munshi,b   Howell G. M. Edwards,b   Edmund H. Linfielda  and  A. Giles Daviesa  

* Corresponding authors

a Institute of Microwaves and Photonics, School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK
E-mail: A.D.Burnett@leeds.ac.uk

b Division of Chemistry with Forensic Science, University of Bradford, Bradford, UK

Abstract

Terahertz frequency time-domain spectroscopy has been used to analyse a wide range of samples containing cocaine hydrochloride, heroin and ecstasy – common drugs-of-abuse. We investigated real-world samples seized by law enforcement agencies, together with pure drugs-of-abuse, and pure drugs-of-abuse systematically adulterated in the laboratory to emulate real-world samples. In order to investigate the feasibility of automatic spectral recognition of such illicit materials by terahertz spectroscopy, principal component analysis was employed to cluster spectra of similar compounds.

Graphical abstract: Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis

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Article information

DOI
https://doi.org/10.1039/B817839A
Article type
Paper
Submitted
13 Oct 2008
Accepted
21 Apr 2009
First published
22 May 2009

Analyst, 2009,134, 1658-1668

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Broadband terahertz time-domain spectroscopy of drugs-of-abuse and the use of principal component analysis

A. D. Burnett, W. Fan, P. C. Upadhya, J. E. Cunningham, M. D. Hargreaves, T. Munshi, H. G. M. Edwards, E. H. Linfield and A. G. Davies, Analyst, 2009, 134, 1658 DOI: 10.1039/B817839A

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