Issue 7, 2008
From the journal:

Chemical Communications

Site isolated base and acid catalyzed azaspirocyclization cascades†

Adam W. Pilling,a   Jutta Böhmerb  and  Darren J. Dixon*a  

* Corresponding authors

a School of Chemistry, The University of Manchester, Oxford Road, Manchester, UK
E-mail: Darren.Dixon@man.ac.uk
Fax: +44 (0)161 2754939
Tel: +44 (0)161 2751426

b Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire, UK

Abstract

A one-pot, site isolated base (PS-BEMP) and acid (Si-TsOH) catalyzed cyclization cascade to azaspirocyclic molecules is reported; the reaction is simple to perform, atom efficient (water is the only byproduct) and broad in its scope to a diverse range of azaspirocyclic products.

Graphical abstract: Site isolated base and acid catalyzed azaspirocyclization cascades

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Article information

DOI
https://doi.org/10.1039/B716568D
Article type
Communication
Submitted
29 Oct 2007
Accepted
14 Dec 2007
First published
03 Jan 2008

Chem. Commun., 2008, 832-834

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Site isolated base and acid catalyzed azaspirocyclization cascades

A. W. Pilling, J. Böhmer and D. J. Dixon, Chem. Commun., 2008, 832 DOI: 10.1039/B716568D

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