Issue 18, 2008
From the journal:

Organic & Biomolecular Chemistry

Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I†

Tatiana Y. Zakharian,a   Luigi Di Costanzoa  and  David W. Christianson*a  

* Corresponding authors

a Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA
E-mail: chris@sas.upenn.edu
Fax: +1 215 573 2201
Tel: +1 215 898 5714

Abstract

The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site.

Graphical abstract: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B811797G
Article type
Communication
Submitted
10 Jul 2008
Accepted
15 Jul 2008
First published
06 Aug 2008

Org. Biomol. Chem., 2008,6, 3240-3243

Permissions

Request permissions

Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

T. Y. Zakharian, L. Di Costanzo and D. W. Christianson, Org. Biomol. Chem., 2008, 6, 3240 DOI: 10.1039/B811797G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements