Issue 20, 2008
From the journal:

Organic & Biomolecular Chemistry

Design and synthesis of intrinsically cell-penetrating nucleopeptides†

Piero Geotti-Bianchini,ab   Julien Beyrath,a   Olivier Chaloin,a   Fernando Formaggio*b  and  Alberto Bianco*a  

* Corresponding authors

a CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunologie et Chimie Thérapeutiques, 15 Rue René Descartes, Strasbourg, France
E-mail: A.Bianco@ibmc.u-strasbg.fr

b Dipartimento di Chimica, Università di Padova, via Marzolo 1, Padova, Italy
E-mail: fernando.formaggio@unipd.it

Abstract

Nucleopeptides, which are constituted of α-amino acids bearing nucleobases at their side chains, are able to penetrate into cells and to reach the nucleus without cytotoxic effects.

Graphical abstract: Design and synthesis of intrinsically cell-penetrating nucleopeptides

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Article information

DOI
https://doi.org/10.1039/B811639C
Article type
Communication
Submitted
08 Jul 2008
Accepted
05 Sep 2008
First published
17 Sep 2008

Org. Biomol. Chem., 2008,6, 3661-3663

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Design and synthesis of intrinsically cell-penetrating nucleopeptides

P. Geotti-Bianchini, J. Beyrath, O. Chaloin, F. Formaggio and A. Bianco, Org. Biomol. Chem., 2008, 6, 3661 DOI: 10.1039/B811639C

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