Issue 3, 2008

Natural products: chemical instruments to apprehend biological symphony

Abstract

As a striking variety of biological activities are elicited by natural products, these chemicals have been used for decades to study biological phenomena. Understanding how these products interfere with normal cell functions at a molecular level led to a wide range of discoveries including new signaling pathways and proteins. Moreover, as natural products often act as chemical inhibitors, such studies often allow the identification of their binding partners as relevant targets for drug design. This article aims to emphasize how natural products or engineered analogs can be used as chemical tools to apprehend some biological problems from the point of view of a chemical biologist.

Graphical abstract: Natural products: chemical instruments to apprehend biological symphony

Article information

Article type
Perspective
Submitted
23 Aug 2007
Accepted
29 Oct 2007
First published
19 Nov 2007

Org. Biomol. Chem., 2008,6, 424-432

Natural products: chemical instruments to apprehend biological symphony

M. Pucheault, Org. Biomol. Chem., 2008, 6, 424 DOI: 10.1039/B713022H

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