Issue 46, 2008
From the journal:

Chemical Communications

Efficient and divergent synthesis of cyclophosphamide analogues from 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans†

Dexuan Xiang,a   Peng Huang,b   Kewei Wang,a   Guangyuan Zhou,b   Yongjiu Liangb  and  Dewen Dong*ab  

* Corresponding authors

a Department of Chemistry, Northeast Normal University, Changchun, China

b Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
E-mail: dongdw663@nenu.edu.cn
Fax: +86 431 8509 8635

Abstract

A facile and efficient one-pot synthesis of substituted cyclophosphamidic chlorides and their analogues has been developed from readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans.

Graphical abstract: Efficient and divergent synthesis of cyclophosphamide analogues from 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans

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Article information

DOI
https://doi.org/10.1039/B815416C
Article type
Communication
Submitted
04 Sep 2008
Accepted
29 Sep 2008
First published
15 Oct 2008

Chem. Commun., 2008, 6236-6238

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Efficient and divergent synthesis of cyclophosphamide analogues from 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans

D. Xiang, P. Huang, K. Wang, G. Zhou, Y. Liang and D. Dong, Chem. Commun., 2008, 6236 DOI: 10.1039/B815416C

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