Issue 38, 2008
From the journal:

Chemical Communications

Detection of mismatched DNAsvia the binding affinity of MutS using a gold nanoparticle-based competitive colorimetric method†

Minseon Cho,a   Min Su Han*b  and  Changill Ban*a  

* Corresponding authors

a Department of Chemistry, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea
E-mail: ciban@postech.ac.kr
Fax: +82 54 279 9929
Tel: +82 54 279 8634

b Department of Chemistry, Chuang-Ang University, Seoul, Republic of Korea
E-mail: mshan@cau.ac.kr
Fax: +82 2 825 4736
Tel: +82 2 820 5198

Abstract

A gold nanoparticle-based competitive colorimetric assay can detect mismatched DNAs using MutS, a mismatch binding protein, and determine their relative binding affinities for this protein by a simple color change and the melting temperature of DNA-functionalized nanoparticle assemblies.

Graphical abstract: Detection of mismatched DNAsvia the binding affinity of MutS using a gold nanoparticle-based competitive colorimetric method

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Article information

DOI
https://doi.org/10.1039/B811346G
Article type
Communication
Submitted
03 Jul 2008
Accepted
05 Aug 2008
First published
01 Sep 2008

Chem. Commun., 2008, 4573-4575

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Detection of mismatched DNAsvia the binding affinity of MutS using a gold nanoparticle-based competitive colorimetric method

M. Cho, M. S. Han and C. Ban, Chem. Commun., 2008, 4573 DOI: 10.1039/B811346G

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