Issue 28, 2008
From the journal:

Chemical Communications

Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy†

Keelara Abiraj,a   Hugues Jaccard,b   Martin Kretzschmar,a   Lothar Helmb  and  Helmut R. Maecke*a  

* Corresponding authors

a Division of Radiological Chemistry, Department of Radiology, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland
E-mail: hmaecke@uhbs.ch
Fax: +41 61 2655559
Tel: +41 61 2654699

b Laboratoire de Chimie Inorganique et Bioinorganique, Ecole Polytechnique Fédérale de Lausanne, EPFL-BCH, CH-1015 Lausanne, Switzerland

Abstract

Dimeric peptidic vectors, obtained by the divalent grafting of bombesin analogues on a newly synthesized DOTA-based prochelator, showed improved qualities as tumor targeted imaging probes in comparison to their monomeric analogues.

Graphical abstract: Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B805281F
Article type
Communication
Submitted
28 Mar 2008
Accepted
24 Apr 2008
First published
20 Jun 2008

Chem. Commun., 2008, 3248-3250

Permissions

Request permissions

Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy

K. Abiraj, H. Jaccard, M. Kretzschmar, L. Helm and H. R. Maecke, Chem. Commun., 2008, 3248 DOI: 10.1039/B805281F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements