Issue 17, 2007
From the journal:

Organic & Biomolecular Chemistry

Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region†

Simon J. Shaw,*a   Hugo G. Menzella,a   David C. Myles,a   Ming Xianb  and  Amos B. Smith III*b  

* Corresponding authors

a Kosan Biosciences, Inc., 3832 Bay Center Place, Hayward, USA
E-mail: shaw@kosan.com
Fax: 01 510 732 8001
Tel: 01 510 731 5269

b Department of Chemistry, University of Pennsylvania, Philadelphia, USA
E-mail: smithab@sas.upenn.edu
Fax: 01 215 898 5192
Tel: 01 215 898 4860

Abstract

Analogues of discodermolide in which the complete C-1 to C-7 fragment is replaced with a coumarin moiety display equivalent potency to that of the natural product.

Graphical abstract: Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

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Article information

DOI
https://doi.org/10.1039/B708884C
Article type
Communication
Submitted
12 Jun 2007
Accepted
12 Jun 2007
First published
18 Jul 2007

Org. Biomol. Chem., 2007,5, 2753-2755

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Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity to the natural product—a further simplification of the lactone region

S. J. Shaw, H. G. Menzella, D. C. Myles, M. Xian and A. B. Smith III, Org. Biomol. Chem., 2007, 5, 2753 DOI: 10.1039/B708884C

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