Issue 11, 2007
From the journal:

Green Chemistry

Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa†

Xuefeng Wang,ab   C. André Ohlin,a   Qinghua Lu,*a   Zhaofu Fei,c   Jun Hub  and  Paul J. Dysonc  

* Corresponding authors

a School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, P.R. China
E-mail: qhlu@sjtu.edu.cn
Fax: +86 021-54747535
Tel: +86 021-54747535

b School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China
E-mail: xuefengwang@sjtu.edu.cn
Tel: +86 021-34203723

c Laboratory of Organometallic and Medicinal Chemistry, Institut des Sciences et Ingénierie Chimique, Swiss Federal Institute of Technology, Lausanne, Switzerland
E-mail: zhaofu.fei@epfl.ch.
Tel: +41 021-6939838

Abstract

The toxicity of ethyl-, butyl-, octyl-, benzyl-, and allyl-substituted 1-alkyl-3-methylimidazolium, alkylpyridinium, N-alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium (choline derivatives) and alkyl-triethylammonium salts towards HeLa cells has been studied. The relative toxicities have been determined in the presence and absence of foetal bovine serum using an MTT assay after 24 and 48 h, and attempts to determine possible sources of the observed toxicity investigated using microscopy and by measuring the intracellular calcium concentration, presence of reactive oxygen species and mitochondrial membrane potential in cells exposed to 1-ethyl-3-methylimidazolium tetrafluoroborate.

Graphical abstract: Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B704503D
Article type
Paper
Submitted
26 Mar 2007
Accepted
19 Jul 2007
First published
03 Aug 2007

Green Chem., 2007,9, 1191-1197

Permissions

Request permissions

Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

X. Wang, C. A. Ohlin, Q. Lu, Z. Fei, J. Hu and P. J. Dyson, Green Chem., 2007, 9, 1191 DOI: 10.1039/B704503D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements