Issue 8, 2006
From the journal:

Chemical Society Reviews

Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes

Gerasimos Malandrinos,a   Maria Louloudi*a  and  Nick Hadjiliadis*a  

* Corresponding authors

a University of Ioannina, Department of Chemistry, Ioannina, Greece
E-mail: mlouloud@cc.uoi.gr (M. Louloudi); nhadjis@cc.uoi.gr (N. Hadjiliadis)
Fax: +30 26510 44831
Tel: +30-26510-98418 (M. Louloudi); +30-26510-98420 (N. Hadjiliadis)

Abstract

Thiamine dependent enzymes catalyze ligase and lyase reactions near a carbonyl moiety. Chemical models for these reactions serve as useful tools to substantiate a detailed mechanism of action. This tutorial review covers all such studies performed thus far, emphasizing the role of each part around the active site and the conformation of the cofactor during catalysis.

Graphical abstract: Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes

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Article information

DOI
https://doi.org/10.1039/B514511M
Article type
Tutorial Review
Submitted
25 Nov 2005
First published
10 Feb 2006

Chem. Soc. Rev., 2006,35, 684-692

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Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes

G. Malandrinos, M. Louloudi and N. Hadjiliadis, Chem. Soc. Rev., 2006, 35, 684 DOI: 10.1039/B514511M

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