Microwave-assisted cyclic amidine synthesis using TiCl4

Abstract

Microwave-assisted treatment of various heterocyclic amides (benzodiazepinone, phthalazone) with TiCl₄ in the presence of primary or secondary amines provides the corresponding amidines. In addition to the interest of the microwaves for this reaction, our study highlights the higher reactivity of the cyclic acetamide moiety compared to the cyclic benzamide moiety towards this TiCl₄-mediated reaction.