A paramagnetic contrast agent with myeloperoxidase-sensing properties†
Abstract
Myeloperoxidase (MPO) is an essential component of inflammatory response in norm and pathology. With an ultimate goal of non-invasive imaging of MPO we used a gadolinium-chelating bis(5-hydroxytrytamide) derivative of diethylenetetraamine pentaacetic acid (L1–Gd3+salt) as a paramagnetic sensor of enzymatic activity. We tested whether L1–Gd3+ is active in reducing the oxidized form of myeloperoxidase, generated as a result of hydrogen peroxide