Issue 3, 2006
From the journal:

Green Chemistry

Selective N-alkylation of anilines in ionic liquids†

Cinzia Chiappe,*a   Paolo Picciolia  and  Daniela Pieraccinia  

* Corresponding authors

a Dipartimento di Chimica Bioorganica e Biofarmacia, via Bonanno 33, Pisa, Italy
E-mail: cinziac@farm.unipi.it
Fax: +39 050 2219660
Tel: +39 050 2219669

Abstract

A simple and efficient method for the preparation of N-monoalkyl-substituted anilines employing ionic liquids (ILs) as the solvent is presented. The reactions have been performed in several ionic liquids using differently substituted anilines as substrates and alkyl, allyl and benzyl halides as alkylating agents in order to establish the factors that affect the reactivity and the chemoselectivity of the N-alkylation process.

Graphical abstract: Selective N-alkylation of anilines in ionic liquids

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Article information

DOI
https://doi.org/10.1039/B509851C
Article type
Paper
Submitted
11 Jun 2005
Accepted
09 Sep 2005
First published
28 Sep 2005

Green Chem., 2006,8, 277-281

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Selective N-alkylation of anilines in ionic liquids

C. Chiappe, P. Piccioli and D. Pieraccini, Green Chem., 2006, 8, 277 DOI: 10.1039/B509851C

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