Issue 9, 2006
From the journal:

Chemical Society Reviews

Glycolipids for natural killer T cells

Paul B. Savage,*a   Luc Teytonc  and  Albert Bendelacb  

* Corresponding authors

a Reed M. Izatt Professor of Chemistry and Biochemistry, Associate Chair, Department of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA
E-mail: paul_savage@byu.edu
Fax: 801-422-0153
Tel: 801-422-4020

b University of Chicago, Chicago, IL 60637, USA

c Scripps Research Institute, La Jolla, CA 92037, USA

Abstract

Natural killer T cells (NKT cells) play a central role in regulating immune responses influencing conditions ranging from autoimmune to infectious diseases. NKT cell responses are induced by recognition of glycolipid antigens presented by CD1d, an antigen presentation protein. In the last 10 years great strides have been made in understanding the types of glycolipids recognized by NKT cells. These advances have included determination of the lipid and carbohydrate recognition requirements for stimulation and identification of “natural” antigens for these cells.

Graphical abstract: Glycolipids for natural killer T cells

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Article information

DOI
https://doi.org/10.1039/B510638A
Article type
Tutorial Review
Submitted
18 Apr 2006
First published
09 Jun 2006

Chem. Soc. Rev., 2006,35, 771-779

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Glycolipids for natural killer T cells

P. B. Savage, L. Teyton and A. Bendelac, Chem. Soc. Rev., 2006, 35, 771 DOI: 10.1039/B510638A

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