Issue 1, 2004
From the journal:

Natural Product Reports

Approaches to identify, clone, and express symbiont bioactive metabolite genes

Mark Hildebrand,a   Laura E. Waggoner,a   Grace E. Lim,a   Katherine H. Sharp,a   Christian P. Ridleya  and  Margo G. Haygood*a  

* Corresponding authors

a Scripps Institution of Oceanography, Marine Biology Research Division; Center for Marine Biotechnology and Biomedicine; and UCSD Cancer Center, University of California, San Diego, California 92093, USA

Abstract

Covering: 1981–2003

This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.

Graphical abstract: Approaches to identify, clone, and express symbiont bioactive metabolite genes

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Article information

DOI
https://doi.org/10.1039/B302336M
Article type
Review Article
Submitted
22 Oct 2003
First published
15 Dec 2003

Nat. Prod. Rep., 2004,21, 122-142

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Approaches to identify, clone, and express symbiont bioactive metabolite genes

M. Hildebrand, L. E. Waggoner, G. E. Lim, K. H. Sharp, C. P. Ridley and M. G. Haygood, Nat. Prod. Rep., 2004, 21, 122 DOI: 10.1039/B302336M

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