Issue 4, 2004

Directed evolution of enzymes for product chemistry

Abstract

Covering: up to April 2004

This review discusses the achievements of directed evolution of enzymes relevant to natural and unnatural product chemistry focusing on the period 1998–2004, citing 156 references. A few selected papers published before 1998 are also cited for their fundamental relevance, together with additional reviews covering other aspects of directed evolution applied to closely related topics. An overview of the latest methods applied in directed evolution is given in the introduction, together with a range of approaches for the selection of variants of enzymes with desired catalytic properties. All classes of enzymes are systematically covered.

Graphical abstract: Directed evolution of enzymes for product chemistry

Article information

Article type
Review Article
Submitted
16 Jun 2004
First published
15 Jul 2004

Nat. Prod. Rep., 2004,21, 490-511

Directed evolution of enzymes for product chemistry

F. Valetti and G. Gilardi, Nat. Prod. Rep., 2004, 21, 490 DOI: 10.1039/B202342N

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