Asymmetric fluorous catalysis: the particular case of nitrogen-containing chiral auxiliaries

Abstract

Asymmetric fluorous biphasic (FB) catalysis has been developed in the last decade in the perspective of creating new recyclable catalytic systems, easy to separate from the reaction products. This approach came after other concepts for the heterogenization of homogeneous ligands, developed for the same purpose. We focus this paper on fluorous nitrogen-containing ligands and compare them to the unfluorinated ones and, when possible, to the same ligands heterogenized in another way. The future of the FB technique is discussed.