Issue 3, 2004
From the journal:

Chemical Communications

Thioglycosynthases: double mutant glycosidases that serve as scaffolds for thioglycoside synthesis†

Michael Jahn,a   Hongming Chen,a   Johannes Müllegger,a   Jennifer Marles,b   R. Antony J. Warrenb  and  Stephen G. Withersa  

a Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C., Canada
E-mail: withers@chem.ubc.ca
Fax: (+1) 604-822-8869
Tel: (+1) 604-822-3402

b Department of Microbiology & Immunology, University of British Columbia, 6174 University Boulevard, Vancouver, B.C., Canada

Abstract

A double mutant, retaining glycosidase that lacks both the catalytic nucleophile and the catalytic acid/base residues efficiently catalyzes thioglycoside formation from a glycosyl fluoride donor and thiosugar acceptors.

Graphical abstract: Thioglycosynthases: double mutant glycosidases that serve as scaffolds for thioglycoside synthesis

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Article information

DOI
https://doi.org/10.1039/B313155F
Article type
Communication
Submitted
20 Oct 2003
Accepted
24 Nov 2003
First published
05 Jan 2004

Chem. Commun., 2004, 274-275

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Thioglycosynthases: double mutant glycosidases that serve as scaffolds for thioglycoside synthesis

M. Jahn, H. Chen, J. Müllegger, J. Marles, R. A. J. Warren and S. G. Withers, Chem. Commun., 2004, 274 DOI: 10.1039/B313155F

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