Issue 21, 2003
From the journal:

Organic & Biomolecular Chemistry

Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis†‡

David P. Gamblin,a   Philippe Garnier,a   Sarah J. Ward,a   Neil J. Oldham,a   Antony J. Fairbanks*a  and  Benjamin G. Davis*a  

* Corresponding authors

a Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK
E-mail: Ben.Davis@chem.ox.ac.uk, Antony.Fairbanks@chem.ox.ac.uk
Fax: +44 1865 275674
Tel: +44 1865 275652

Abstract

Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.

Graphical abstract: Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

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Article information

DOI
https://doi.org/10.1039/B306990G
Article type
Communication
Submitted
19 Jun 2003
Accepted
28 Jul 2003
First published
11 Aug 2003

Org. Biomol. Chem., 2003,1, 3642-3644

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Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

D. P. Gamblin, P. Garnier, S. J. Ward, N. J. Oldham, A. J. Fairbanks and B. G. Davis, Org. Biomol. Chem., 2003, 1, 3642 DOI: 10.1039/B306990G

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