Issue 5, 2002

Sterically hindered benzoates: a synthetic strategy for modeling dioxygen activation at diiron active sites in proteins

Abstract

Bulky terphenyl carboxylates and related benzyl-substituted benzoates have been used to assemble a variety of new diiron complexes analogous to nonheme diiron protein active sites. Through this conceptually simple approach, novel biomimetic structures have been accessed and biologically relevant oxidized intermediates and products have been isolated and characterized by both spectroscopic and X-ray crystallographic methods. Interesting similarities and differences in the observed chemistry of the iron(II) complexes, including ligand substitution and dioxygen activation reactions, result from variation of the specific carboxylate and accompanying N-donor ligand structures. As a result, new insights have been obtained into structure/function relationships in carboxylate-rich nonheme diiron proteins.

Graphical abstract: Sterically hindered benzoates: a synthetic strategy for modeling dioxygen activation at diiron active sites in proteins

Article information

Article type
Perspective
Submitted
12 Sep 2001
Accepted
08 Oct 2001
First published
22 Jan 2002

J. Chem. Soc., Dalton Trans., 2002, 653-660

Sterically hindered benzoates: a synthetic strategy for modeling dioxygen activation at diiron active sites in proteins

W. B. Tolman and L. Que, Jr., J. Chem. Soc., Dalton Trans., 2002, 653 DOI: 10.1039/B108262K

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