Synthesis and tastant properties of disulfamates. Multisulfamation studies
Abstract
Twenty four disulfamates, one trisulfamate, two tetrasulfamates and two monosulfamates have been made. The disulfamates are of two types: RN(SO3Na)2 (Type A, compounds 1–20) and NaO3S(H)NR′N(H)SO3Na (Type B, compounds 21–24) and all except three (which had not been tasted) are new materials. The positions of the –SO3Na groups in compounds 21–23 have been established by the use of model compounds (e.g. parent CHN(R)SO3− might function as a hydrogen source in the Shallenberger–Acree, multicomponent attachment and α-helical