Issue 6, 2001
From the journal:

Journal of the Chemical Society, Dalton Transactions

ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionine †

Qin Liu,ab   Junyong Zhang,a   Xiaokang Ke,a   Yuhua Mei,a   Longgen Zhua  and  Zijian Guo*a  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, Nanjing, P.R. China
E-mail: zguo@netra.nju.edu.cn
Fax: (+86)-25 3314502

b Department of Food Sciences and Engineering, Nanjing College of Economics, Nanjing, P.R. China

Abstract

The reactions of L-selenomethionine (L-Se-MetH) with cisplatin, cis-[PtCl2(NH3)2], were investigated using electrospray mass spectroscopy (ESMS) and 2-D [1H–15N] NMR spectroscopy. The reaction intermediates and products identified were cis-[PtCl(L-Se-MetH)(NH3)2]+, cis-[Pt(L-Se-Met)(NH3)2]+, [PtCl(L-Se-MetH)(NH3)]+ and [Pt(L-Se-Met)(L-Se-MetH)]+. Some binuclear adducts were also detected by ESMS during the reaction, although they existed in minor amounts. Similar reactions with L-MetH were also conducted under similar conditions for comparison. This work provides the first detailed studies on the reaction of a platinum-based drug with L-Se-MetH.

Graphical abstract: ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionine [ ]

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Article information

DOI
https://doi.org/10.1039/B008611H
Article type
Paper
Submitted
25 Oct 2000
Accepted
22 Jan 2001
First published
19 Feb 2001

J. Chem. Soc., Dalton Trans., 2001, 911-916

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ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionine

Q. Liu, J. Zhang, X. Ke, Y. Mei, L. Zhu and Z. Guo, J. Chem. Soc., Dalton Trans., 2001, 911 DOI: 10.1039/B008611H

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